Hamish D. Toop

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

Nigel Turner, Xin Ying Lim, Hamish D. Toop et al. · Nature Communications · 2018 · 140 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease

Jennifer Batson, Hamish D. Toop, Clara Redondo et al. · ACS Chemical Biology · 2017 · 108 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity

Jing Jing Li, Hock L. Tay, Steven Maltby et al. · Journal of Allergy and Clinical Immunology · 2015 · 93 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +12

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4

Konstantinos Tzelepis, Étienne De Braekeleer, Demetrios Aspris et al. · Nature Communications · 2018 · 88 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors

Amanda M. Smith, Matthew D. Dun, Erwin M. Lee et al. · Oncotarget · 2016 · 48 citations · Full text

Medicine, Oncology, Pharmacology +17