Demetrios Aspris

Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia

Eliza Yankova, Wesley Blackaby, Mark R. Albertella et al. · Nature · 2021 · 1.3K citations · Full text

Medicine, Oncology, Pharmacology +13

Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control

Isaia Barbieri, Konstantinos Tzelepis, Luca Pandolfini et al. · Nature · 2017 · 1.1K citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +13

METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation

Esteban A. Orellana, Qi Liu, Eliza Yankova et al. · Molecular Cell · 2021 · 362 citations · Full text

Medicine, Cancer Biology, Molecular Biology +7

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4

Konstantinos Tzelepis, Étienne De Braekeleer, Demetrios Aspris et al. · Nature Communications · 2018 · 88 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

meCLICK-Seq, a Substrate-Hijacking and RNA Degradation Strategy for the Study of RNA Methylation

Sigitas Mikutis, Muxin Gu, Erdem Sendinc et al. · ACS Central Science · 2020 · 61 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +17