Benzodiazepine Peptidomimetics: Potent Inhibitors of Ras Farnesylation In Animal Cells

Guy L. James, Joseph L. Goldstein, Michael S. Brown, +7

Science

From Peptide to Non-Peptide. 2. The de Novo Design of Potent, Non-peptidal Inhibitors of Platelet Aggregation Based on a Benzodiazepinedione Scaffold

Robert S. McDowell, Brent Blackburn, Thomas R. Gadek, +6

Journal of the American Chemical Society

Altmetric Attention ScorePeptide SciencePharmacotherapyPeptide TherapeuticsChemical Biology +20

A Class of 2,4-Bisanilinopyrimidine Aurora A Inhibitors with Unusually High Selectivity against Aurora B

Ignacio Aliagas-Martin, Dan Burdick, Laura Corson, +18

Journal of Medicinal Chemistry

Molecular BiologyOrganic ChemistryPharmacotherapyAurora BChemistry +14

Potent α4β1 Peptide Antagonists as Potential Anti-Inflammatory Agents

David Y. Jackson, Clifford Quan, Dean R. Artis, +14

Journal of Medicinal Chemistry

Cell AdhesionImmune RegulationImmunologyPeptide ScienceImmune System +18

In vitro characterization of four novel classes of growth hormone-releasing peptide.

Kathleen A. Elias, Gladys S. Ingle, John P. Burnier, +6

Endocrinology

Vitro CharacterizationGrowth Hormone-releasing PeptideHuman GrowthPeptide SciencePeptide Therapeutics +19

A Pentacyclic Aurora Kinase Inhibitor (AKI-001) with High in Vivo Potency and Oral Bioavailability

Thomas E. Rawson, Matthias Rüth, Elizabeth Blackwood, +27

Journal of Medicinal Chemistry

Medicinal ChemistryOral BioavailabilityNovel TherapyMedicineVivo Potency +12

Benzodiazepine peptidomimetic inhibitors of farnesyltransferase

James C. Marsters, Robert S. McDowell, Mark E. Reynolds, +13

Bioorganic & Medicinal Chemistry

Medicinal ChemistryMedicinePharmacotherapyBenzodiazepine Peptidomimetic InhibitorsDrug Development +2

A Selective, Slow Binding Inhibitor of Factor VIIa Binds to a Nonstandard Active Site Conformation and Attenuates Thrombus Formation in Vivo

Alan G. Olivero, Charles Eigenbrot, Richard Goldsmith, +16

Journal of Biological Chemistry

Crystal StructureMolecular BiologyThrombosisFviia Active SiteHematology +20

The synthesis of chiral 3-oxo-6-[(phenylmethoxy)-carbonyl]-2-piperazineacetic acid esters designed for the presentation of an aspartic acid side chain. A subsequent novel Friedel Crafts reaction

Timothy P. Kogan, Thomas E. Rawson

Tetrahedron Letters

EngineeringBiochemistryNatural SciencesOrganic ChemistryStereoselective Synthesis +5

Preparation and biological activity of novel tricyclic GPIIb/IIIa antagonists

Kirk Robarge, Michael S. Dina, Todd C. Somers, +8

Bioorganic & Medicinal Chemistry

Biological ActivityMedicinal ChemistryNatural SciencesMedicinePharmacological Agent +4