Brian M. Lacey

An orally available non-nucleotide STING agonist with antitumor activity

Bo‐Sheng Pan, Samanthi A. Perera, Jennifer Piesvaux et al. · Science · 2020 · 609 citations

Antitumor Activity, Immunology, Immunoediting +19

Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING

Tony Siu, Michael D. Altman, Gretchen A. Baltus et al. · ACS Medicinal Chemistry Letters · 2018 · 163 citations · Full text

Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of<i>Pseudomonas aeruginosa</i>

Seungil Han, Richard P. Zaniewski, Eric S. Marr et al. · Proceedings of the National Academy of Sciences · 2010 · 159 citations · Full text

Hydration Site Energies, Biomolecular Structure Prediction, Molecular Biology +26

Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer

Wonsuk Chang, Michael D. Altman, Charles A. Lesburg et al. · Journal of Medicinal Chemistry · 2022 · 122 citations · Full text

Immunology, Molecular Biology, Interferon Genes +17

Clinically Relevant Gram-Negative Resistance Mechanisms Have No Effect on the Efficacy of MC-1, a Novel Siderophore-Conjugated Monocarbam

Craig J. McPherson, Lisa Aschenbrenner, Brian M. Lacey et al. · Antimicrobial Agents and Chemotherapy · 2012 · 89 citations · Full text

Immunology, Pharmacotherapy, Antimicrobial Chemotherapy +23