Fabio Begnini

Mining Natural Products for Macrocycles to Drug Difficult Targets

Fabio Begnini, Vasanthanathan Poongavanam, Björn Over et al. · Journal of Medicinal Chemistry · 2020 · 45 citations · Full text

NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner

Fakhar H. Waqas, Mahmoud Shehata, Walid A. M. Elgaher et al. · PLoS Pathogens · 2023 · 43 citations · Full text

Viral Replication, Lipid Peroxidation, Viral Pathogenesis +18

Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1–Nrf2 Protein–Protein Interaction

Fabio Begnini, Stefan Geschwindner, Patrik Johansson et al. · Journal of Medicinal Chemistry · 2022 · 35 citations · Full text

Drug Target, Keap1 Binding Site, Oxidative Stress +16

Sequential Multicomponent Strategy for the Diastereoselective Synthesis of Densely Functionalized Spirooxindole-Fused Thiazolidines

Giulia Rainoldi, Fabio Begnini, Mariska de Munnik et al. · ACS Combinatorial Science · 2018 · 28 citations · Full text

Combinatorial Chemistry, Engineering, Heterocyclic +15

Cell Permeability of Isomeric Macrocycles: Predictions and NMR Studies

Fabio Begnini, Vasanthanathan Poongavanam, Yoseph Atilaw et al. · ACS Medicinal Chemistry Letters · 2021 · 27 citations · Full text

Passive Permeability, Engineering, Flexible Macrocycles +15