siRNA-directed inhibition of HIV-1 infection

Carl D. Novina, Michael F. Murray, Derek M. Dykxhoorn, +7

Nature Medicine

MedicineHuman RetrovirusImmunologyAntiviral Drug DevelopmentVirology +4

Tumor Suppressor NM23-H1 Is a Granzyme A-Activated DNase during CTL-Mediated Apoptosis, and the Nucleosome Assembly Protein SET Is Its Inhibitor

Zusen Fan, Paul J. Beresford, David Y. Oh, +2

Cell

ChromatinChromatin RemodelingTumor Suppressor Nm23-h1Natural SciencesDna Replication +9

The Exonuclease TREX1 Is in the SET Complex and Acts in Concert with NM23-H1 to Degrade DNA during Granzyme A-Mediated Cell Death

Dipanjan Chowdhury, Paul J. Beresford, Pengcheng Zhu, +5

Molecular Cell

ChromatinGenome InstabilitySet ComplexChromatin RemodelingNatural Sciences +8

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

Zusen Fan, Paul J. Beresford, Dong Zhang, +5

Nature Immunology

MedicineLipid PeroxidationApoptosisImmunologyCell Death +7

Granzyme A Loading Induces Rapid Cytolysis and a Novel Form of DNA Damage Independently of Caspase Activation

Paul J. Beresford, Zhinan Xia, Arnold H. Greenberg, +1

Immunity

Genome InstabilityDna Damage IndependentlyBiochemistryCellular EnzymologyNatural Sciences +7

Granzyme A Activates an Endoplasmic Reticulum-associated Caspase-independent Nuclease to Induce Single-stranded DNA Nicks

Paul J. Beresford, Dong Zhang, David Y. Oh, +5

Journal of Biological Chemistry

Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis

Dong Zhang, Paul J. Beresford, Arnold H. Greenberg, +1

Proceedings of the National Academy of Sciences

HMG2 Interacts with the Nucleosome Assembly Protein SET and Is a Target of the Cytotoxic T-Lymphocyte Protease Granzyme A

Zusen Fan, Paul J. Beresford, Dong Zhang, +1

Molecular and Cellular Biology

ChromatinGenome InstabilityProtein FunctionHmg Box AChromatin Remodeling +13

Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them

Paul J. Beresford, Chih-Min Kam, James C. Powers, +1

Proceedings of the National Academy of Sciences

HlaHistocompatibilityHla ImmunogeneticsImmunologyMolecular Biology +17

Induction of Rapid Histone Degradation by the Cytotoxic T Lymphocyte Protease Granzyme A

Dong Zhang, Mark S. Pasternack, Paul J. Beresford, +3

Journal of Biological Chemistry