Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells

Daniel DiToro, Colleen J. Winstead, Duy Pham, +16

Science

Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition

Peng Wu, Tongtong Zhang, Baoyu Liu, +21

Molecular Cell

HistocompatibilitySignal TransductionImmune Effector FunctionsPeptide-mhc ClassImmunology +5

Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen

Justin J. Taylor, Ryan J. Martinez, Philip J. Titcombe, +6

The Journal of Experimental Medicine

Autoimmune DiseasePolyclonal B CellsEnrichment StrategyImmunologyUbiquitous Membrane-bound Self-antigen +11

B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation

Benjamin G. Barwick, Christopher D. Scharer, Ryan J. Martinez, +6

Nature Communications

Arthritogenic Self-Reactive CD4+ T Cells Acquire an FR4hiCD73hi Anergic State in the Presence of Foxp3+ Regulatory T Cells

Ryan J. Martinez, Na Zhang, Stephanie R. Thomas, +4

The Journal of Immunology

T-regulatory CellImmunologyCd4 T Cell ResponsesPeripheral Cd4Inflammatory Arthritis +14

Low-affinity CD4+ T cells are major responders in the primary immune response

Ryan J. Martinez, Rakieb Andargachew, Hunter A. Martinez, +1

Nature Communications

Type 2 cytokines in the thymus activate Sirpα+ dendritic cells to promote clonal deletion

Elise R. Breed, Matouš Vobořil, K. Maude Ashby, +6

Nature Immunology

InflammationCytokineImmune Cell DevelopmentClonal DeletionImmunology +11

Low-Affinity Memory CD8+ T Cells Mediate Robust Heterologous Immunity

Scott M. Krummey, Ryan J. Martinez, Rakieb Andargachew, +6

The Journal of Immunology

Cd45rb StatusTransplantationAutoimmune DiseaseHigh Cd45rb StatusAdaptive Immune System +13

Is interval appendectomy really needed? A closer look at neoplasm rates in adult patients undergoing interval appendectomy after complicated appendicitis

Danielle Hayes, Shelby Reiter, Gary Lucas, +3

Surgical Endoscopy

Surgical OncologyAdult PatientsOutcomes ResearchCloser LookSurgery +6

Type III interferon drives thymic B cell activation and regulatory T cell generation

Ryan J. Martinez, Elise R. Breed, Yosan Worota, +7

Proceedings of the National Academy of Sciences