Viral delivery of miR-196a ameliorates the SBMA phenotype via the silencing of CELF2

Yu Miyazaki, Hiroaki Adachi, Masahisa Katsuno, +11

Nature Medicine

ImmunologyRna BiologyViral DeliverySbma PhenotypeMicrorna Detection +6

Silencing neuronal mutant androgen receptor in a mouse model of spinal and bulbar muscular atrophy

Kentaro Sahashi, Masahisa Katsuno, Gene Hung, +7

Human Molecular Genetics

Androgen ReceptorSocial SciencesSkeletal MuscleNeuroendocrine MechanismDegenerative Pathology +16

p62/SQSTM1 Differentially Removes the Toxic Mutant Androgen Receptor via Autophagy and Inclusion Formation in a Spinal and Bulbar Muscular Atrophy Mouse Model

Hideki Doi, Hiroaki Adachi, Masahisa Katsuno, +12

Journal of Neuroscience

Androgen ReceptorMitophagyCell DeathP62/sqstm1 DifferentiallyCellular Physiology +18

Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration

Naohide Kondo, Masahisa Katsuno, Hiroaki Adachi, +13

Nature Communications

Neurodegenerative DiseasesHyperthermiaMedicineBrain InjuryNeuroscience +6

Paeoniflorin eliminates a mutant AR via NF-YA-dependent proteolysis in spinal and bulbar muscular atrophy

Genki Tohnai, Hiroaki Adachi, Masahisa Katsuno, +12

Human Molecular Genetics

Pioglitazone suppresses neuronal and muscular degeneration caused by polyglutamine-expanded androgen receptors

Madoka Iida, Masahisa Katsuno, Hideaki Nakatsuji, +9

Human Molecular Genetics

Androgen ReceptorPolyglutamine-expanded Androgen ReceptorsMitochondrial DysfunctionGlucocorticoidSocial Sciences +24

Protective effect of a molecular chaperone inducer, paeoniflorin, on the HCl- and ethanol-triggered gastric mucosal injury

Midori Asai, Daisuke Kawashima, Kiyoe Katagiri, +3

Life Sciences

InflammationGastrointestinal Peptide HormoneAnti-inflammatoryBiochemistryMedicine +6

Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS

Tomoki Hirunagi, Kentaro Sahashi, Kiyoshi Tachikawa, +12

Molecular Therapy — Nucleic Acids

Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy

Madoka Iida, Kentaro Sahashi, Naohide Kondo, +15

Nature Communications

DNA methylation inhibitor attenuates polyglutamine‐induced neurodegeneration by regulating Hes5

Naohide Kondo, Genki Tohnai, Kentaro Sahashi, +11

EMBO Molecular Medicine