A Powerful Approach to Estimating Annotation-Stratified Genetic Covariance via GWAS Summary Statistics

Qiongshi Lu, Boyang Li, Derek Ou, +12

The American Journal of Human Genetics

Genome-wide Association StudyGenetic AnalysisHaplotype DeterminationGenotype-phenotype AssociationMedicine +11

CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies

William W. Feng, Owen M. Wilkins, Scott Bang, +17

Cell Reports

Breast OncologyMetabolic RemodelingCancer BiologyTumor BiologyFa Synthesis +17

Leveraging functional annotations in genetic risk prediction for human complex diseases

Yiming Hu, Qiongshi Lu, Ryan L. Powles, +5

PLoS Computational Biology

GeneticsPolygenic RiskGenetic EpidemiologyBayesian FrameworkHuman Complex Diseases +19

Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer’s disease

Qiongshi Lu, Ryan L. Powles, Sarah B. Abdallah, +9

PLoS Genetics

GeneticsImmunologyHeritability EnrichmentImmune SystemNeuroinflammation +20

Integrative Tissue-Specific Functional Annotations in the Human Genome Provide Novel Insights on Many Complex Traits and Improve Signal Prioritization in Genome Wide Association Studies

Qiongshi Lu, Ryan L. Powles, Qian Wang, +2

PLoS Genetics

GeneticsGenomicsGene Expression ProfilingEpigeneticsGenome-wide Association Studies +19

Scalable and cost-effective NGS genotyping in the cloud

Yassine Souilmi, Alex K. Lancaster, Jae-Yoon Jung, +7

BMC Medical Genomics

DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell–mediated antitumor immunity

Michael Wichroski, Joseph L. Benci, Si-Qi Liu, +26

Science Translational Medicine

Pd-1 BlockadeImmunologyImmunoeditingAntitumor ImmunityImmunotherapeutics +20

Leveraging Functional Annotations in Genetic Risk Prediction for Human Complex Diseases

Yiming Hu, Qiongshi Lu, Ryan L. Powles, +4

GeneticsPolygenic RiskGenetic EpidemiologyHuman Complex DiseasesGenome-wide Association Studies +20

Association of T-Cell Receptor Repertoire Use With Response to Combined Trastuzumab-Lapatinib Treatment of HER2-Positive Breast Cancer

Ryan L. Powles, David Redmond, Christos Sotiriou, +13

JAMA Oncology

Analysis of Pre- and Posttreatment Tissues from the SWOG S0800 Trial Reveals an Effect of Neoadjuvant Chemotherapy on the Breast Cancer Genome

Ryan L. Powles, Vikram B. Wali, Xiaotong Li, +6

Clinical Cancer Research