Elevated serum myostatin level is associated with worse survival in patients with liver cirrhosis

Hiroki Nishikawa, Hirayuki Enomoto, Akio Ishii, +15

Journal of Cachexia Sarcopenia and Muscle

(E)-1,3-Dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists

Junichi Shimada, Fumio Suzuki, Hiromi Nonaka, +2

Journal of Medicinal Chemistry

Altmetric Attention ScorePharmacotherapySystem PharmacologyChemical BiologyPharmaceutical Chemistry +16

Inhibition by topiramate of seizures in spontaneously epileptic rats and DBA/2 mice

Joji Nakamura, Sachiko Tamura, Tomoyuki Kanda, +5

European Journal of Pharmacology

NeurophysiologyMedicineSynaptic TransmissionNeuropharmacologySocial Sciences +10

Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-[(R)-phenylisopropyl]adenosine-induced cognitive disturbance

Fumio Suzuki, Junichi Shimada, Shizuo Shiozaki, +6

Journal of Medicinal Chemistry

Molecular PharmacologyAdenosine A1 AntagonistsNeuropeptidesBiochemistryFunctional Selectivity +13

Chromosome Abnormalities of Leukemia Cells in Adult Patients With T-Cell Leukemia

Kanji Miyamoto, Noriko Tomita, Akio Ishii, +4

JNCI Journal of the National Cancer Institute

Hematological MalignancyChromatinCytogeneticsMixed-phenotype Acute LeukemiaAdult T-cell Leukemia +11

8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors

Junichi Shimada, Fumio Suzuki, Hiromi Nonaka, +1

Journal of Medicinal Chemistry

Medicinal ChemistryA1 Receptor SiteA1-adenosine ReceptorsBiochemistryG Protein-coupled Receptor +10

The teleost Oryzias latipes shows telomere shortening with age despite considerable telomerase activity throughout life

Hitoshi Hatakeyama, Kenichi Nakamura, Naotaka Izumiyama‐Shimomura, +4

Mechanisms of Ageing and Development

BiologyLifespan ExtensionTeleost OryziasAgingLongevity +5

Topiramate reduces abnormally high extracellular levels of glutamate and aspartate in the hippocampus of spontaneously epileptic rats (SER)

Tomoyuki Kanda, Masako Kurokawa, Sachiko Tamura, +7

Life Sciences

NeurophysiologyMedicineNeurotransmitterNeuropharmacologyNeuroprotection +9

Decreased expression of nucleoside diphosphate kinase α isoform, annm23-H2 gene homolog, is associated with metastatic potential of rat mammary-adenocarcinoma cells

Mitsugu Fukuda, Akio Ishii, Yoshiro Yasutomo, +7

International Journal of Cancer

PathologyCancer BiologyMammary Gland DevelopmentTumor BiologyRat Mammary-adenocarcinoma Cells +15

Telomeric DNA length in cerebral gray and white matter is associated with longevity in individuals aged 70 years or older

Kenichi Nakamura, Kaiyo Takubo, Naotaka Izumiyama‐Shimomura, +8

Experimental Gerontology

Lifespan ExtensionAgingLongevityGeneticsTelomeric Dna Length +9