Adenosine A_2A Antagonist: A novel antiparkinsonian agent that does not provoke dyskinesia in Parkinsonian monkeys

Tomoyuki Kanda, Michael Jackson, Lance A. Smith, +5

Annals of Neurology

Combined Use of the Adenosine A2A Antagonist KW-6002 with l-DOPA or with Selective D1 or D2 Dopamine Agonists Increases Antiparkinsonian Activity but Not Dyskinesia in MPTP-Treated Monkeys

Tomoyuki Kanda, Michael S. Jackson, Lance A. Smith, +5

Experimental Neurology

NeurophysiologyMedicineSelective D1Functional SelectivityNeuropharmacology +9

Actions of adenosine A 2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP

Shizuo Shiozaki, Shunji Ichikawa, Joji Nakamura, +3

Psychopharmacology

NeurophysiologyMedicineDrug-induced CatalepsyPhysiologyFunctional Selectivity +7

Studies on cardiotonic agents. II. Synthesis of novel phthalazine and 1,2,3-benzotriazine derivatives.

Yuji Nomoto, H. OBASE, H. TAKAI, +1

Chemical and Pharmaceutical Bulletin

Anesthetized DogsOrganic ChemistryPharmacotherapyNovel PhthalazinePharmaceutical Chemistry +15

KF17837: A novel selective adenosine A2A receptor antagonist with anticataleptic activity

Tomoyuki Kanda, Shizuo Shiozaki, Junichi Shimada, +2

European Journal of Pharmacology

Molecular PharmacologyFunctional SelectivityMedicineMechanism Of ActionReceptor (Biochemistry) +6

Systemic administration of adenosine A2A receptor antagonist reverses increased GABA release in the globus pallidus of unilateral 6-hydroxydopamine-lesioned rats: a microdialysis study

Mayumi Ochi, Kumiko Koga, Masako Kurokawa, +3

Neuroscience

NeurophysiologyMedicineMicrodialysis StudyPhysiologySystemic Administration +8

Adenosine A2A receptor antagonists KF17837 and KW-6002 potentiate rotation induced by dopaminergic drugs in hemi-Parkinsonian rats

Kumiko Koga, Masako Kurokawa, Mayumi Ochi, +2

European Journal of Pharmacology

Hemi-parkinsonian RatsFunctional SelectivityMedicinePhysiologyKw-6002 Potentiate Rotation +6

Adenosine A2A antagonists with potent anti-cataleptic activity

Junichi Shimada, Nobuaki Koike, Hiromi Nonaka, +8

Bioorganic & Medicinal Chemistry Letters

MedicineAdenosine A2aPharmacotherapyAnesthesiaPharmacology +2

Adenosine A_2a Receptor‐Mediated Modulation of Striatal Acetylcholine Release In Vivo

Masako Kurokawa, Kumiko Koga, Hiroshi Kase, +2

Journal of Neurochemistry

Inhibition by topiramate of seizures in spontaneously epileptic rats and DBA/2 mice

Joji Nakamura, Sachiko Tamura, Tomoyuki Kanda, +5

European Journal of Pharmacology

NeurophysiologyMedicineSynaptic TransmissionNeuropharmacologySocial Sciences +10