Shigeru Akimoto

Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2-bromovinyl)uracil that increases the level and toxicity of 5-fluorouracil

Haruyuki Nakayama, Takemi Kinouchi, Keiko Kataoka et al. · Pharmacogenetics · 1997 · 120 citations

High Blood Concentration, Immunology, Antibiotic Resistance +18

Gastric acid reduction leads to an alteration in lower intestinal microflora

Takayuki Kanno, Takahiro Matsuki, Masashi Oka et al. · Biochemical and Biophysical Research Communications · 2009 · 110 citations

Nutrition, Dysbiosis, Medicine +13

Complete Sequencing and Diversity Analysis of the Enterotoxin-Encoding Plasmids in<i>Clostridium perfringens</i>Type A Non-Food-Borne Human Gastrointestinal Disease Isolates

Kazuaki Miyamoto, Derek J. Fisher, Jihong Li et al. · Journal of Bacteriology · 2006 · 96 citations · Full text

Enterotoxin Gene, Cpe Plasmids, Microbial Pathogens +20

Genetic Characterization of Type A Enterotoxigenic Clostridium perfringens Strains

Agi Deguchi, Kazuaki Miyamoto, Tomomi Kuwahara et al. · PLoS ONE · 2009 · 88 citations · Full text

Microbial Toxin, Type A, Genetics +13

Prevalence and Characterization of Enterotoxin Gene-Carrying<i>Clostridium perfringens</i>Isolates from Retail Meat Products in Japan

Yasuhiro Miki, Kazuaki Miyamoto, Ikuko Kaneko-Hirano et al. · Applied and Environmental Microbiology · 2008 · 85 citations · Full text