Mutation in <i>TET2</i> in Myeloid Cancers

François Delhommeau, Sabrina Dupont, Véronique Della Valle, +20

New England Journal of Medicine

TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis

Cyril Quivoron, Lucile Couronné, Véronique Della Valle, +20

Cancer Cell

Recurrent EventLymphoid NeoplasiaLymphocyte DevelopmentMalignant Blood DisorderT-regulatory Cell +7

Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants

Ilyas Chachoua, C. Pecquet, Mira El-Khoury, +15

Blood

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells

Emilie Rass, Anastazja Grabarz, Isabelle Plo, +3

Nature Structural & Molecular Biology

ChromatinGenome InstabilityChromatin StructureMedicineNatural Sciences +6

Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis

Caroline Marty, C. Pecquet, Harini Nivarthi, +9

Blood

Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions

Isabelle Plo

DNA repair

ChromatinGenome InstabilityMolecular BiologyPathologyDna Phosphodiesterase +1

Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients

Xénia Cabagnols, Fabrizia Favale, Florence Pasquier, +18

Blood

A role for reactive oxygen species in JAK2V617F myeloproliferative neoplasm progression

Caroline Marty, Catherine Lacout, Nathalie Droin, +6

Leukemia

Hematological MalignancyTumor BiologyMedicineHematologyPathology +6

Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors

Elodie Pronier, Carole Almire, Hayat Mokrani, +17

Blood

JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders

Isabelle Plo, Mayuka Nakatake, Laurent Malivert, +5

Blood