Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants

Ilyas Chachoua, C. Pecquet, Mira El-Khoury, +15

Blood

Whole-exome sequencing identifies novel MPL and JAK2 mutations in triple-negative myeloproliferative neoplasms

Jelena D. Milosevic Feenstra, Harini Nivarthi, Heinz Gisslinger, +17

Blood

Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis

Caroline Marty, C. Pecquet, Harini Nivarthi, +9

Blood

Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients

Xénia Cabagnols, Fabrizia Favale, Florence Pasquier, +18

Blood

WNT signaling and AHCTF1 promote oncogenic MYC expression through super-enhancer-mediated gene gating

Barbara A. Scholz, Noriyuki Sumida, Carolina Diettrich Mallet de Lima, +10

Nature Genetics

Signal TransductionSignaling PathwayOncogenic Myc ExpressionCell RegulationGenetics +8

Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defective pathogenic TpoR mutants

C. Pecquet, Ilyas Chachoua, Anita Roy, +18

Blood

Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms

C. Pecquet, Nicolas Papadopoulos, Thomas Balligand, +39

Blood

PathologyMolecular BiologyCytoskeletonMutant CalrCancer Biology +18

Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation

Michael Girardot, C. Pecquet, Ilyas Chachoua, +11

Oncogene

Hematological MalignancySystems BiologyCell RegulationPersistent Stat5 ActivationGene Regulation +8

Secreted Mutant Calreticulins As Rogue Cytokines Trigger Thrombopoietin Receptor Activation Specifically in CALR Mutated Cells: Perspectives for MPN Therapy

C. Pecquet, Thomas Balligand, Ilyas Chachoua, +27

Blood

Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site

Ilyas Chachoua, Ilias Tzelepis, Hao Dai, +11

Nature Communications