Alexandra K. Leamy

Palmitate-induced Activation of Mitochondrial Metabolism Promotes Oxidative Stress and Apoptosis in H4IIEC3 Rat Hepatocytes

Robert A. Egnatchik, Alexandra K. Leamy, Yasushi Noguchi et al. · Metabolism · 2013 · 163 citations · Full text

Life Sciences, Biochemistry, Cell Biology +16

ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload

Robert A. Egnatchik, Alexandra K. Leamy, David A. Jacobson et al. · Molecular Metabolism · 2014 · 156 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Enhanced synthesis of saturated phospholipids is associated with ER stress and lipotoxicity in palmitate treated hepatic cells

Alexandra K. Leamy, Robert A. Egnatchik, Masakazu Shiota et al. · Journal of Lipid Research · 2014 · 128 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Glutamate–oxaloacetate transaminase activity promotes palmitate lipotoxicity in rat hepatocytes by enhancing anaplerosis and citric acid cycle flux

Robert A. Egnatchik, Alexandra K. Leamy, Sarah A. Sacco et al. · Journal of Biological Chemistry · 2018 · 35 citations · Full text

Life Sciences, Biochemistry, Cell Biology +14

Knockdown of triglyceride synthesis does not enhance palmitate lipotoxicity or prevent oleate-mediated rescue in rat hepatocytes

Alexandra K. Leamy, Clinton M. Hasenour, Robert A. Egnatchik et al. · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · 2016 · 22 citations

Life Sciences, Biochemistry, Cell Biology +16