Pentadecapeptide BPC 157 and its effects on a NSAID toxicity model: Diclofenac-induced gastrointestinal, liver, and encephalopathy lesions

Spomenko Ilić, Domagoj Drmić, Sandra Franjić, +19

Life Sciences

MedicineNsaid Toxicity ModelPharmacotherapyExperimental PharmacologyEncephalopathy Lesions +4

High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats. A counteraction with the stable gastric pentadecapeptide BPC 157 (PL 14736).

Spomenko Ilić, Domagoj Drmić, K. Žarković, +16

PubMed

Brain DamageHepatologyMedicineLiver PhysiologyGastroenterology +13

Pentadecapeptide BPC 157 Reduces Bleeding and Thrombocytopenia after Amputation in Rats Treated with Heparin, Warfarin, L-NAME and L-Arginine

Mirjana Stupnišek, Antonio Kokot, Domagoj Drmić, +9

PLoS ONE

Pentadecapeptide BPC 157 reduces bleeding time and thrombocytopenia after amputation in rats treated with heparin, warfarin or aspirin

Mirjana Stupnišek, Sandra Franjić, Domagoj Drmić, +7

Thrombosis Research

ThrombosisReduces Bleeding TimeCardiovascular DiseaseBlood PlateletStroke +13

Tissue distribution of lipid peroxidation product acrolein in human colon carcinogenesis

Kamelija Žarković, Kôji Uchida, Danijela Kolenc, +2

Free Radical Research

Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability.

Robert Kliček, Danijela Kolenc, Jelena Šuran, +11

PubMed

Drinking WaterGastrointestinal Peptide HormoneMotor DisabilityGastrointestinal PharmacologyClinical Nutrition +13

Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats

Spomenko Ilić, Domagoj Drmić, Kamelija Žarković, +10

European Journal of Pharmacology

Gastric LesionIbuprofen Hepatic EncephalopathyHepatologyMedicineLiver Physiology +5

Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME

Domagoj Drmić, Danijela Kolenc, Spomenko Ilić, +7

World Journal of Gastroenterology

Effects of Diclofenac, L-NAME, L-Arginine, and Pentadecapeptide BPC 157 on Gastrointestinal, Liver, and Brain Lesions, Failed Anastomosis, and Intestinal Adaptation Deterioration in 24 Hour-Short-Bowel Rats

Nermin Lojo, Žarko Rašić, Anita Zenko Sever, +7

PLoS ONE

Over-dose insulin and stable gastric pentadecapeptide BPC 157. Attenuated gastric ulcers, seizures, brain lesions, hepatomegaly, fatty liver, breakdown of liver glycogen, profound hypoglycemia and calcification in rats.

Spomenko Ilić, Iva Brčić, Mester de Parajd M, +14

PubMed

GastroenterologyInsulin SignalingGastrointestinal Peptide HormoneMetabolic SyndromeOver-dose Insulin +16