Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody

Cheng Li, Wuqiang Zhan, Zhenlin Yang, +21

Cell

Sars-cov-2 VariantsBroad NeutralizationVaccine TargetImmunologyVirology +4

A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants

Zhenlin Yang, Yulu Wang, Yujia Jin, +23

Signal Transduction and Targeted Therapy

DNAzyme-based faithful probing and pulldown to identify candidate biomarkers of low abundance

Qinqin Hu, Zong-Xuan Tong, Ayimukedisi Yalikong, +15

Nature Chemistry

BiologyDna BarcodingDna SequencingLow AbundanceGenetics +13

An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope

Zezhong Liu, Wei Xu, Zhenguo Chen, +25

Protein & Cell

Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies

Ying-Dan Wang, Xiang Zhang, Yunping Ma, +15

Cell Discovery

Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer

Wuqiang Zhan, Xiaolong Tian, Xiang Zhang, +10

Journal of Virology

Asymmetric pendrin homodimer reveals its molecular mechanism as anion exchanger

Qianying Liu, Xiang Zhang, Hui Huang, +15

Nature Communications

Dynamic molecular architecture and substrate recruitment of cullin3–RING E3 ligase CRL3KBTBD2

Yuxia Hu, Zhao Zhang, Qiyu Mao, +13

Nature Structural & Molecular Biology

Protein AssemblyMolecular RegulationDynamic Molecular ArchitectureNatural SciencesProtein X-ray Crystallography +5

Fortuitous Somatic Mutations during Antibody Evolution Endow Broad Neutralization against SARS-CoV-2 Omicron Variants

Jianbo Wu, Zhenguo Chen, Yidan Gao, +19

ImmunogeneticsSystems BiologyFortuitous Somatic MutationsViral EvolutionSomatic Variant +11

Asymmetric Pendrin Homodimer Reveals its Molecular Mechanism as Anion Exchanger

Qianying Liu, Xiang Zhang, Hui Huang, +15