Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition

Yael Cohen‐Sharir, James M. McFarland, Mai Abdusamad, +23

Nature

Genome InstabilityCell DivisionMedicineImmune Checkpoint InhibitorMitotic Checkpoint Inhibition +4

Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy

Marica Rosaria Ippolito, Valentino Martis, Sara L. Martin, +10

Developmental Cell

ChromatinGenome InstabilityCytogeneticsChromosomal InstabilityGenetics +8

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage

Johanna Zerbib, Marica Rosaria Ippolito, Yonatan Eliezer, +25

Nature Communications

ChromatinGenome InstabilityHuman CellDna DamageCell Regulation +9

Increased RNA and Protein Degradation Is Required for Counteracting Transcriptional Burden and Proteotoxic Stress in Human Aneuploid Cells

Marica Rosaria Ippolito, Johanna Zerbib, Yonatan Eliezer, +26

Cancer Discovery

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage

Johanna Zerbib, Marica Rosaria Ippolito, Yonatan Eliezer, +13

Dna DamageCytogeneticsGeneticsCell DeathRaf/mek/erk Pathway +18

Chromosome 7 Gain Compensates for Chromosome 10 Loss in Glioma

Nishanth Ulhas Nair, Alejandro A. Schäffer, E. Michael Gertz, +8

Cancer Research

Ritanserin, a potent serotonin 2A receptor antagonist, represses MEK/ERK signalling pathway to restore PAX6 production and function in aniridia-like cellular model

Keren Oved, Léa Zennaro, Orly Dorot, +6

Biochemical and Biophysical Research Communications

Signal TransductionMedicinePax6 ProductionNeurotransmitterReceptor Antagonist +6

Feeder-free culture of human pluripotent stem cells drives MDM4-mediated gain of chromosome 1q

Dylan Stavish, Christopher J. Price, Gabriele Gelezauskaite, +19

Stem Cell Reports

Aneuploidy-driven genome instability triggers resistance to chemotherapy

Marica Rosaria Ippolito, Valentino Martis, Christy Hong, +6

Karyotype ImbalanceGenome InstabilityCell DivisionCytogeneticsTumor Heterogeneity +9

A compendium of Amplification-Related Gain Of Sensitivity genes in human cancer

Verónica Rendo, Michaël Schubert, Nicholas Khuu, +26

Nature Communications