Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

Brandon B. Holmes, Sarah L. DeVos, Najla Kfoury, +11

Proceedings of the National Academy of Sciences

Protein SecretionSpecific Proteopathic SeedsGlycobiologyMolecular BiologyProtein Aggregates +20

Binding of the Radioligand SIL23 to α-Synuclein Fibrils in Parkinson Disease Brain Tissue Establishes Feasibility and Screening Approaches for Developing a Parkinson Disease Imaging Agent

Devika P. Bagchi, Lihai Yu, Joel S. Perlmutter, +4

PLoS ONE

Molecular BiologyNeurochemical BiomarkersSynaptic SignalingDegenerative PathologyProtein Misfolding +17

Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils

Wenhua Chu, Dong Zhou, Vrinda Gaba, +12

Journal of Medicinal Chemistry

Peptide ScienceChemical BiologyPharmaceutical ChemistryMolecular PharmacologyDegenerative Pathology +14

Wnt/β-catenin signaling regulates adipose tissue lipogenesis and adipocyte-specific loss is rigorously defended by neighboring stromal-vascular cells

Devika P. Bagchi, Akira Nishii, Ziru Li, +7

Molecular Metabolism

Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits

Ziru Li, Emily Bowers, Junxiong Zhu, +13

eLife

Identification and Dissection of Diverse Mouse Adipose Depots

Devika P. Bagchi, Ormond A. MacDougald

Journal of Visualized Experiments

Metabolic DisorderAdipokinesInsulin SignalingObesityMetabolic Syndrome +16

Synthesis and in vitro evaluation of α-synuclein ligands

Lihai Yu, Jinquan Cui, Prashanth K. Padakanti, +4

Bioorganic & Medicinal Chemistry

PharmacologyBioconjugationα-Synuclein Ligands

Constitutive bone marrow adipocytes suppress local bone formation

Ziru Li, Devika P. Bagchi, Junxiong Zhu, +12

JCI Insight

G-CSF partially mediates effects of sleeve gastrectomy on the bone marrow niche

Ziru Li, Julie Hardij, Simon S. Evers, +17

Journal of Clinical Investigation

Circulating NeutrophilsSleeve GastrectomyImmunologyBlood CellSurgery +15

Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction

Devika P. Bagchi, Ziru Li, Callie A.S. Corsa, +7

Molecular Metabolism