Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

David E. Gordon, Joseph Hiatt, Mehdi Bouhaddou, +303

Science

Viral DiagnosticsCovid-19 PandemicViral PathogenesisImmunologyMolecular Biology +10

Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses

Ruofan Wang, Camille R. Simoneau, Jessie Kulsuptrakul, +17

Cell

Viral EvolutionViral DiagnosticsCommon Cold CoronavirusesPathogenesisImmunology +3

Assembly of CRISPR ribonucleoproteins with biotinylated oligonucleotides via an RNA aptamer for precise gene editing

Jared Carlson-Stevermer, Amr A. Abdeen, Lucille Kohlenberg, +4

Nature Communications

A tortoise–hare pattern seen in adapting structured and unstructured populations suggests a rugged fitness landscape in bacteria

Joshua Nahum, Peter Godfrey‐Smith, Brittany N. Harding, +3

Proceedings of the National Academy of Sciences

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage

Jichao Sun, Jared Carlson-Stevermer, Utpal Das, +16

Nature Communications

Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication

Caroline G. Williams, Alexander S. Jureka, Jesus A. Silvas, +6

Cell Reports

Lipid SynthesisBiochemistryMedicineNatural SciencesAntiviral Drug Development +10

CRISPRoff enables spatio-temporal control of CRISPR editing

Jared Carlson-Stevermer, Reed Kelso, Anastasia P. Kadina, +5

Nature Communications

Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen

Alice Mac Kain, Ghizlane Maarifi, Sophie‐Marie Aicher, +22

Nature Communications

Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets

Kelsey M. Haas, Michael McGregor, Mehdi Bouhaddou, +52

Nature Communications

Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses

Ruofan Wang, Camille R. Simoneau, Jessie Kulsuptrakul, +9