Classification and mutation prediction from non–small cell lung cancer histopathology images using deep learning

Nicolas Coudray, Paolo Ocampo, Theodore Sakellaropoulos, +6

Nature Medicine

Mutation PredictionEngineeringMachine LearningMedical ImagingDeep Learning +10

Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment

Xufeng Chen, Christina Glytsou, Hua Zhou, +12

Cancer Discovery

A Deep Learning Framework for Predicting Response to Therapy in Cancer

Theodore Sakellaropoulos, Konstantinos Vougas, Sonali Narang, +20

Cell Reports

Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries

Yixiao Gong, Charalampos Lazaris, Theodore Sakellaropoulos, +5

Nature Communications

Strong BoundariesEngineeringGeneticsEpigeneticsTad Boundary Strength +19

H3K27ac bookmarking promotes rapid post-mitotic activation of the pluripotent stem cell program without impacting 3D chromatin reorganization

Bobbie Pelham‐Webb, Alexander Polyzos, Luke Wojenski, +7

Molecular Cell

ChromatinEmbryonic Stem CellLineage PlasticityDevelopmental BiologyCell Regulation +10

Cell-type-specific prediction of 3D chromatin organization enables high-throughput in silico genetic screening

Jimin Tan, Nina Shenker-Tauris, Javier Rodriguez-Hernaez, +9

Nature Biotechnology

GeneticsMolecular BiologyGene Regulatory NetworkGenomicsChromatin Accessibility +23

Classification and Mutation Prediction from Non-Small Cell Lung Cancer Histopathology Images using Deep Learning

Nicolas Coudray, André L. Moreira, Theodore Sakellaropoulos, +3

Mutation PredictionConvolutional Neural NetworkMedical Image SegmentationEngineeringMachine Learning +23

NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains

Priscillia Lhoumaud, Sana Badri, Javier Rodriguez-Hernaez, +9

Nature Communications

Histone ModificationsInsulated DomainsEpigenetic ChangeGeneticsTranscriptional Changes +20

Selective cytotoxicity of the herbal substance acteoside against tumor cells and its mechanistic insights

Christina Cheimonidi, Pinelopi Samara, Panagiotis Polychronopoulos, +13

Redox Biology

ImmunologyPathologySelective CytotoxicityTumor CellsActeoside Inhibits +15

The species translation challenge—A systems biology perspective on human and rat bronchial epithelial cells

Carine Poussin, Carole Mathis, Leonidas G. Alexopoulos, +16

Scientific Data

EngineeringLung InflammationImmunologyCellular PhysiologyTranslational Biology +20