Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice

Youren Tong, Hiroo Yamaguchi, Emilie Giaime, +4

Proceedings of the National Academy of Sciences

Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia

Scott Boyle, Andrew Misfeldt, Kelly J. Chandler, +5

Developmental Biology

Cell LineageDevelopmental BiologyCell DivisionMedicineFate Mapping +10

The Extracellular Domain of Notch2 Increases Its Cell-Surface Abundance and Ligand Responsiveness during Kidney Development

Zhenyi Liu, Shuang Chen, Scott Boyle, +5

Developmental Cell

Differential Expression of the Intermediate Filament Protein Nestin during Renal Development and Its Localization in Adult Podocytes

Jing Chen, Scott Boyle, Min Zhao, +7

Journal of the American Society of Nephrology

Protein SecretionIntermediate Filament ProteinNestin ExpressionCytoskeletonNephrology +18

Cited1 and Cited2 are differentially expressed in the developing kidney but are not required for nephrogenesis

Scott Boyle, Toshi Shioda, Alan O. Perantoni, +1

Developmental Dynamics

The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage

Kameswaran Surendran, Scott Boyle, Hila Barak, +4

Developmental Biology

Renal FunctionDevelopmental BiologyMedicineRenal PathologyRenal Inflammation +8

Cited1 Is a Bifunctional Transcriptional Cofactor That Regulates Early Nephronic Patterning

Sergey Plisov, Michael Tsang, Genbin Shi, +7

Journal of the American Society of Nephrology

GeneticsGene Regulatory NetworkEarly Nephronic PatterningTranscriptional RegulationSignaling Pathway +20

SpDamID: Marking DNA Bound by Protein Complexes Identifies Notch-Dimer Responsive Enhancers

Matthew R. Hass, Hien-haw Liow, Xiaoting Chen, +13

Molecular Cell

ChromatinNatural SciencesMarking Dna BoundGenomic MechanismDna Replication +6

CITED1 Expression in Wilms' Tumor and Embryonic Kidney

Harold N. Lovvorn, Jenifer Westrup, Shaun Opperman, +7

Neoplasia

Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity

Zhenyi Liu, Eric W. Brunskill, Scott Boyle, +5

Development