Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma

Mitsuteru Natsuizaka, Kelly A. Whelan, Shingo Kagawa, +20

Nature Communications

Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells

Takashi Kijima, Hiroshi Nakagawa, Masataka Shimonosono, +28

Cellular and Molecular Gastroenterology and Hepatology

Tumor BiologyEsophageal CancerMedicinePathologyCancer Biology +7

A NOTCH3-Mediated Squamous Cell Differentiation Program Limits Expansion of EMT-Competent Cells That Express the ZEB Transcription Factors

Shinya Ohashi, Mitsuteru Natsuizaka, Seiji Naganuma, +12

Cancer Research

Invasive GrowthCancer BiologyTumor BiologyZinc Finger E-box-bindingTissue Development +18

Fibroblast growth factor-2–mediated FGFR/Erk signaling supports maintenance of cancer stem-like cells in esophageal squamous cell carcinoma

Osamu Maehara, Goki Suda, Mitsuteru Natsuizaka, +20

Carcinogenesis

IGFBP3 promotes esophageal cancer growth by suppressing oxidative stress in hypoxic tumor microenvironment.

Mitsuteru Natsuizaka, Hideaki Kinugasa, Shingo Kagawa, +13

PubMed

Esophageal CancerPathologyEsophageal Cancer GrowthCancer BiologyRedox Biology +16

Regeneration of injured intestinal mucosa is impaired in hepatocyte growth factor activator-deficient mice

Hiroshi Itoh, Seiji Naganuma, Naoki Takeda, +12

Gastroenterology

InflammationRegenerative MedicineLiver PhysiologyGastroenterologyPathology +9

Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities

Shunsuke Kagawa, Mitsuteru Natsuizaka, Kelly A. Whelan, +13

Oncogene

Tumor-suppressor ActivitiesCell RegulationMedicineDifferential Notch1-dependent OncogenicCellular Senescence +5

Expression of MicroRNAs associated with Gleason grading system in prostate cancer: miR‐182‐5p is a useful marker for high grade prostate cancer

Katsuki Tsuchiyama, Hideaki Ito, Minekatsu Taga, +5

The Prostate

Risk factors for early death after liver resection in patients with solitary hepatocellular carcinoma

Kazuhiro Kondo, Kazuo Chijiiwa, Ichiro Makino, +4

Journal of Hepato-Biliary-Pancreatic Surgery

Liver ResectionSurgical OncologyHepatologyMedicineEarly Death +10

Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF‐1α‐mediated mRNA transcription and continuous protein synthesis

Mitsuteru Natsuizaka, Seiji Naganuma, Shingo Kagawa, +9

The FASEB Journal