Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Jiřina Bártková, Nousin Rezaei, Michalis Liontos, +22

Nature

Oncogene-induced SenescenceChromatinGenome InstabilityDna DamageOncogenic Agent +9

SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas

Adam J. Bass, Hideo Watanabe, Craig H. Mermel, +45

Nature Genetics

Tumor BiologyOncogenic AgentMedicineAmplified Lineage-survival OncogenePathology +7

Epidermal Growth Factor Receptor Mediates Increased Cell Proliferation, Migration, and Aggregation in Esophageal Keratinocytes in Vitro and in Vivo

Claudia D. Andl, Takaaki Mizushima, Hiroshi Nakagawa, +5

Journal of Biological Chemistry

Cutaneous BiologyImmunologyEgfr OverexpressionEpithelial-mesenchymal InteractionsCell Proliferation +12

Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase

Priya Aggarwal, Laura Pontano Vaites, J. Kim, +8

Cancer Cell

Cancer ResearchMedicineEpigeneticsCell CycleTumor Suppressor +7

Human mesenchymal stem cells successfully improve skin-substitute wound healing

Hiroshi Nakagawa, Sadanori Akita, M. Fukui, +2

British Journal of Dermatology

Akt/Protein Kinase B Isoforms Are Differentially Regulated by Epidermal Growth Factor Stimulation

Jun‐ichi Okano, Irphan Gaslightwala, Morris J. Birnbaum, +2

Journal of Biological Chemistry

Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation.

Hideki Harada, Hiroshi Nakagawa, Kenji Oyama, +7

PubMed

Skin DevelopmentGenome InstabilityDevelopmental BiologyCell RegulationCell Division +12

Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma

Mitsuteru Natsuizaka, Kelly A. Whelan, Shingo Kagawa, +20

Nature Communications

Sox2 Cooperates with Inflammation-Mediated Stat3 Activation in the Malignant Transformation of Foregut Basal Progenitor Cells

Kuancan Liu, Ming Jiang, Yun Lu, +13

Cell stem cell

InflammationDevelopmental BiologySignaling PathwayCell InteractionImmunology +7

Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion

Katharine D. Grugan, Charles G. Miller, Yao Yao, +8

Proceedings of the National Academy of Sciences