Molecular signatures of antitumor neoantigen-reactive T cells from metastatic human cancers

Frank J. Lowery, Sri Krishna, Rami Yossef, +39

Science

mRNA vaccine–induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer

Gal Cafri, Jared J. Gartner, Tal Zaks, +16

Journal of Clinical Investigation

Phenotypic signatures of circulating neoantigen-reactive CD8+ T cells in patients with metastatic cancers

Rami Yossef, Sri Krishna, Sivasish Sindiri, +22

Cancer Cell

Cancer ImmunosurveillanceMedicineImmunologyPhenotypic SignaturesPathology +7

Adoptive transfer of personalized neoantigen-reactive TCR-transduced T cells in metastatic colorectal cancer: phase 2 trial interim results

Maria R. Parkhurst, Stephanie L. Goff, Frank J. Lowery, +22

Nature Medicine

Cell TherapyCancer ImmunosurveillanceMedicineImmunologyMetastatic Colorectal Cancer +6

Identification and Validation of T-cell Receptors Targeting <i>RAS</i> Hotspot Mutations in Human Cancers for Use in Cell-based Immunotherapy

Noam Levin, Biman C. Paria, Nolan R. Vale, +14

Clinical Cancer Research

Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes

Noam Levin, Sanghyun P. Kim, Charles Marquardt, +20

Journal for ImmunoTherapy of Cancer

Rapid Identification and Evaluation of Neoantigen-reactive T-Cell Receptors From Single Cells

Biman C. Paria, Noam Levin, Frank J. Lowery, +11

Journal of Immunotherapy

Membrane-attached Cytokines Expressed by mRNA Electroporation Act as Potent T-Cell Adjuvants

Hadas Weinstein-Marom, Aviad Pato, Noam Levin, +7

Journal of Immunotherapy

T-regulatory CellImmunologyImmune RegulationImmunoeditingImmunologic Mechanism +25

Spontaneous Activation of Antigen-presenting Cells by Genes Encoding Truncated Homo-Oligomerizing Derivatives of CD40

Noam Levin, Aviad Pato, Gal Cafri, +5

Journal of Immunotherapy

Trimeric LigandAdaptive Immune SystemImmunologyImmune RegulationMolecular Biology +24

Potent Activation of Human T Cells by mRNA Encoding Constitutively Active CD40

Noam Levin, Hadas Weinstein-Marom, Aviad Pato, +6

The Journal of Immunology