Concepedia
Statistics
Publications
22
Citations
2.1K
H-Index
20
Active since
1994
Affiliations
Alectos (Canada)(Current)
Simon Fraser University
Merck & Co., Inc., Rahway, NJ, USA (United States)
United States Military Academy
Stanford University
Ernest J. McEachern is an author at Alectos (Canada) specializing in chemistry, organic chemistry, and natural sciences.
Publications per year
1994–2020
A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo
Scott A. Yuzwa, Matthew S. Macauley, Julia Heinonen et al. · Nature Chemical Biology · 2008 · 704 citations · Full text
Life Sciences, Biochemistry, Medicinal Chemistry +10
Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice
Nicholas B. Hastings, Xiaohai Wang, Lixin Song et al. · Molecular Neurodegeneration · 2017 · 154 citations · Full text
Life Sciences, Neuroscience, Pharmacology +17
Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice
Scott A. Yuzwa, Xiaoyang Shan, Bryan A. Jones et al. · Molecular Neurodegeneration · 2014 · 151 citations · Full text
Life Sciences, Neurology, Neuroscience +17
A Two-Component Catalyst System for Asymmetric Allylic Alkylations with Alcohol Pronucleophiles
Barry M. Trost, Ernest J. McEachern, F. Dean Toste · Journal of the American Chemical Society · 1998 · 144 citations
Natural Sciences, Chemistry, Catalysis +8
Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies
Harold G. Selnick, J. Fred Hess, Cuyue Tang et al. · Journal of Medicinal Chemistry · 2019 · 136 citations · Full text
Pharmacy, Medicinal Chemistry, Pharmacology +17
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