Concepedia
Statistics
Publications
23
Citations
2K
H-Index
20
Active since
1992
Affiliations
Alectos (Canada)(Current)
Simon Fraser University
Merck & Co., Inc., Rahway, NJ, USA (United States)
United States Military Academy
Stanford University
Ernest J. McEachern is an author at Alectos (Canada) specializing in organic chemistry, chemistry, and engineering.
Top concepts
ChemistryEngineeringOrganic ChemistryPharmacologyBiomolecular EngineeringMedicineNatural SciencesBiochemistryDrug DiscoveryCatalysis
Publications per year
1992–2020
A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo
Scott A. Yuzwa, Matthew S. Macauley, Julia Heinonen et al. · Nature Chemical Biology · 2008 · 691 citations · Full text
Signal Transduction, Biochemistry, G Protein-coupled Receptor +9
Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice
Scott A. Yuzwa, Xiaoyang Shan, Bryan A. Jones et al. · Molecular Neurodegeneration · 2014 · 149 citations · Full text
Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice
Nicholas B. Hastings, Xiaohai Wang, Lixin Song et al. · Molecular Neurodegeneration · 2017 · 148 citations · Full text
A Two-Component Catalyst System for Asymmetric Allylic Alkylations with Alcohol Pronucleophiles
Barry M. Trost, Ernest J. McEachern, F. Dean Toste · Journal of the American Chemical Society · 1998 · 143 citations
Cross-coupling Reaction, Engineering, Alkene Metathesis +14
Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies
Harold G. Selnick, J. Fred Hess, Cuyue Tang et al. · Journal of Medicinal Chemistry · 2019 · 134 citations · Full text
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