Neurology · 2013 · 24 citations · 0 references
MedicinePharmacokineticsPharmacologyBioavailabilityClinical PharmacologyDrug MetabolismCytochrome P450 EnzymesCytochrome P450-mediated MetabolismDrug DispositionCyp2d6 Drug MetabolismCyp2d6-guided DosingDeuterium ChemistryHalf-life DifferencesSafety Profile Characterization
OBJECTIVE: To compare the pharmacokinetics (PK) of deuterated-tetrabenazine (SD-809) and tetrabenazine (TBZ) and their respective metabolites.