Concepedia

Release mechanisms of tacrolimus-loaded PLGA and PLA microspheres and immunosuppressive effects of the microspheres in a rat heart transplantation model

Ryo Kojima, Takatsune Yoshida, Hiroaki Tasaki, Hiroyuki Umejima, Masashi Maeda, Yasuyuki Higashi, Shunsuke Watanabe, Naoto Oku

International Journal of Pharmaceutics · 2015 · 29 citations · 29 references

Concepts

MechanobiologyCell-based Drug DeliveryRelease MechanismsEngineeringImmunosuppressive TherapyPhysiologyImmunologyTacrolimus-loaded PlgaPla MicrospheresBiomedical EngineeringMedicineCell TransplantationExtracellular Matrix

References

29

Improved technique of heart transplantation in rats

Keiji Ono, Edward S. Lindsey · Journal of Thoracic and Cardiovascular Surgery · 1969 · 1.3K citations

Heart Failure, Transplantation, Physiology +6

Preparation of microspheres by the solvent evaporation technique

Patrick B. O’Donnell, James W. McGinity · Advanced Drug Delivery Reviews · 1997 · 794 citations

Chemical Engineering, Engineering, Microfabrication +4

Degradation rates of oral resorbable implants (polylactates and polyglycolates): Rate modification with changes in PLA/PGA copolymer ratios

Robert A. Miller, John M. Brady, Duane E. Cutright · Journal of Biomedical Materials Research · 1977 · 713 citations

Tissue Engineering, Engineering, Biomaterials Design +16

Opportunities to Optimize Tacrolimus Therapy in Solid Organ Transplantation: Report of the European Consensus Conference

Pierre Wallemacq, Victor W. Armstrong, Merçè Brunet et al. · Therapeutic Drug Monitoring · 2009 · 453 citations

Uniform Dose, Solid Organ Transplantation, Transplantation Medicine +22

RELATIONSHIP OF FK506 WHOLE BLOOD CONCENTRATIONS AND EFFICACY AND TOXICITY AFTER LIVER AND KIDNEY TRANSPLANTATION

Ronald P. Kershner, William E. Fitzsimmons · Transplantation · 1996 · 308 citations