Chemical changes in muscle

Abstract

in their researches on lactic acid in amphibian muscle found that a fairly definite amount of lactic acid was produced on stimulation to fatigue and that a larger amount accumulated when the muscle was allowed to pass into rigor. Later, Meyerhof [1920, 1921] demonstrated that under anaerobic conditions this lactic acid production was accompanied by an equivalent decrease in the glycogen present. If the muscle was suspended in an alkaline phosphate solution all the glycogen became converted into lactic acid.