Cysteine residues in Cu,Zn-superoxide dismutase are essential to toxicity in Caenorhabditis elegans model of amyotrophic lateral sclerosis

Superoxide Dismutase

Joe M. McCord, Irwin Fridovich · Journal of Biological Chemistry · 1969 · 12.8K citations · Full text

Life Sciences, Biochemistry, Enzymology +11

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

D.R. Rosen, Teepu Siddique, David T. Patterson et al. · Nature · 1993 · 7K citations

Life Sciences, Genetics, Neuroscience +14

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

Lucie Bruijn, Megan K. Houseweart, Shinsuke Kato et al. · Science · 1998 · 1.2K citations

Life Sciences, Neurobiology, Neuroscience +17

EGG-LAYING DEFECTIVE MUTANTS OF THE NEMATODE <i>CAENORHABDITIS ELEGANS</i>

Carol Trent, Nancy Tsung, H. Robert Horvitz · Genetics · 1983 · 748 citations · Full text

Life Sciences, Developmental Biology, Genetics +11

Decreased Metallation and Activity in Subsets of Mutant Superoxide Dismutases Associated with Familial Amyotrophic Lateral Sclerosis

Lawrence J. Hayward, Jorge Rodríguez, Ji Won Kim et al. · Journal of Biological Chemistry · 2002 · 389 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17