The novel HDAC inhibitor AR-42-induced anti-colon cancer cell activity is associated with ceramide production

Cancer statistics, 2014

Rebecca L. Siegel, Jiemin Ma, Zhaohui Zou et al. · CA A Cancer Journal for Clinicians · 2014 · 11.6K citations · Full text

Medicine, Oncology, Cancer Epidemiology +16

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

Ron Bose, Marcel Verheij, Adriana Haimovitz‐Friedman et al. · Cell · 1995 · 836 citations · Full text

Life Sciences, Cancer Biology, Cell Biology +15

Daunorubicin‐induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis.

J P Jaffrézou, Thierry Levade, Christine Bezombes et al. · The EMBO Journal · 1996 · 372 citations · Full text

Life Sciences, Biochemistry, Pharmacology +16

Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ.

Alfred H. Merrill, G. van Echten, E Wang et al. · Journal of Biological Chemistry · 1993 · 370 citations · Full text

Life Sciences, Biochemistry, Neuroscience +17

AR-42, a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit

Tzu‐yin Lin, Joelle M. Fenger, Sridhar Murahari et al. · Blood · 2010 · 78 citations · Full text

Medicine, Oncology, Pharmacology +5