Mitogen-activated protein kinase-activated protein kinase 2 mediates resistance to hydrogen peroxide-induced oxidative stress in human hepatobiliary cancer cells

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

John Rouse, Philip Cohen, Sylviane Trigon et al. · Cell · 1994 · 1.7K citations

Signal Transduction, Mapkap Kinase-2, Signaling Pathway +11

MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis

Alexey Kotlyarov, Armin Neininger, Carola Schubert et al. · Nature Cell Biology · 1999 · 755 citations

Signal Transduction, Signaling Pathway, Mapkap Kinase 2 +4

p53-Deficient Cells Rely on ATM- and ATR-Mediated Checkpoint Signaling through the p38MAPK/MK2 Pathway for Survival after DNA Damage

Hans Christian Reinhardt, Aaron Aslanian, Jacqueline A. Lees et al. · Cancer Cell · 2007 · 592 citations · Full text

P53-deficient Cells Rely, Genome Instability, P38mapk/mk2 Pathway +8

Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

David Stokoe, Katrin Engel, David G. Campbell et al. · FEBS Letters · 1992 · 572 citations · Full text

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.

David Stokoe, David G. Campbell, Sara Nakielny et al. · The EMBO Journal · 1992 · 480 citations · Full text

Signal Transduction, Molecular Physiology, Mapkap Kinase-2 +12