Interleukin-18 for predicting the development of macrophage activation syndrome in systemic juvenile idiopathic arthritis

International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001.

Ross E. Petty, T. R. E. Southwood, Prudence Manners et al. · PubMed · 2004 · 4.2K citations · Full text

Medicine, Clinical Sciences, Pediatric Rheumatology +9

Cloning of a new cytokine that induces IFN-γ production by T cells

Haruki Okamura, Hiroko Tsutsui, Toshinori Komatsu et al. · Nature · 1995 · 2.6K citations

Life Sciences, Biotechnology, Immunology +16

Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function

Osamu Adachi, Taro Kawai, Kiyoshi Takeda et al. · Immunity · 1998 · 2K citations · Full text

Life Sciences, Immunology, Molecular Biology +14

Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial

Shumpei Yokota, Tomoyuki Imagawa, Masaaki Mori et al. · The Lancet · 2008 · 797 citations

Medicine, Clinical Sciences, Pharmacotherapy +8

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

Scott Canna, Adriana A. de Jesus, Sushanth Gouni et al. · Nature Genetics · 2014 · 735 citations · Full text

Life Sciences, Immunology, Molecular Genetics +14