Korean Journal of Food Science and Technology · 1998 · 32 citations · 0 references
MedicinePharmacologyPharmacotherapyCardiovascular PharmacotherapyExperimental PharmacologyMolecular PharmacologyBlood Pressure ControlBlood Pressure ManagementCardiovascular PharmacologyHypertension ControlHypertension ManagementHypertension PharmacotherapyAntihypertensive Drug TherapyAntihypertensive TreatmentBlood PressureChitosanChitosan OligosaccharidesRenin-angiotensin System InhibitorsRenin-angiotensin-aldosterone System InhibitionRenin-angiotensin-aldosterone System Inhibitors
Effect of chitosan oligosaccharides on the ACE (angiotensin I converting enzyme) inhibition and antihypertension in SHR (Spontaneously hypertensive rat) was examined. The ACE inhibition activity was observed in all the chitosan oligosaccharides used in this study, and chitosan trimer exhibited the highest inhibitory activity compared with other chitosan oligosaccharides . The results suggested that chitosan trimer was a good inhibitor of ACE in molecular level. When the single oral dose (2.14 mg/kg, similar to dose level of Captopril, known as strong ACE inhibitor) of chitosan trimer was given to 8 or 21 week aged SHR, the blood pressure reduction of both SHRs in 4hrs were , respectively. Therefore, it was suggested that chitosan trimer could be applicable as natural ACE inhibitor related to antihypertension.