Effects of ${\beta}-Glucan$ from Agaricus blazei Murill on Blood Glucose and Lipid Composition in db/db Mice

Abstract

Obesity and diabetes mellitus are associated with common pathogenic mechanism, and of Agaricus blazei Murill is potent inhibitor of intestinal and inhibit the digestion of starch and sucrose in the small intestine. In this studies, there was observed the anti-hyperglycemic effect in obese diabetic mice(C57BLKsJ db/db), which were supplied Agaricus and Acarbose for 5 weeks. In db/db mice, food intake and body weight gain were decreased significantly in Agaricus groups(p of Agaricus blazei Murill has anti-hyperglycemic and anti-obesitic effects by reducing food intake and body weight gain, and also decreasing serum glucose and lipid level through inhibiting the activity of small intestinal disaccharidases.