Lowering the p K a of a bisimidazoline lead with halogen atoms results in improved activity and selectivity against Trypanosoma brucei in vitro

Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity

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The Alamar Blue® assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro

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Selective reduction of aromatic nitro compounds with stannous chloride in non acidic and non aqueous medium

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Natural Sciences, Chemical Engineering, Chemistry +9

Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space

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Pharmacy, Medicinal Chemistry, Pharmacology +17

Loss of the High-Affinity Pentamidine Transporter Is Responsible for High Levels of Cross-Resistance between Arsenical and Diamidine Drugs in African Trypanosomes

Daniel J. Bridges, Matthew K. Gould, Barbara Nerima et al. · Molecular Pharmacology · 2007 · 141 citations

Life Sciences, Pharmacology, Antimicrobial Resistance +16