How β-Lactamases Have Driven Pharmaceutical Drug Discovery

The structure of β-lactamases

R P Ambler · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1980 · 1.8K citations

Class B, Homology Group, Antibiotics +12

An Enzyme from Bacteria able to Destroy Penicillin

E. P. Abraham, E. B. Chain · Nature · 1940 · 1.3K citations

Health Sciences, Antibiotics, Antibacterial Agent +7

Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-D-alanyl-D-alanine.

Donald J. Tipper, Jack L. Strominger · Proceedings of the National Academy of Sciences · 1965 · 985 citations

In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

Jon H. Condra, William A. Schleif, O M Blahy et al. · Nature · 1995 · 978 citations

Protease Inhibitors, Human Retrovirus, Immunology +10

Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxime in clinical isolates of Klebsiella pneumoniae and Serratia marcescens

H Knothe, Parul Shah, V. Krčméry et al. · Infection · 1983 · 911 citations

Antimicrobial Susceptibility, Health Sciences, Antibiotics +10