Expression Pattern and Prognostic Significance of Claudin 1, 4 and 7 in Pancreatic Cancer

Abstract

Claudins have important functions other than their popular function known as adhesion. Supporting this hypothesis, we found a statistically significant relationship between increased Claudin 7 expression and increased survival time, and this suggests that Claudin 7 may exert different tumorigenic effects in pancreatic cancer other than its well- known adhesion effect.