Long noncoding RNA HOTAIR, a hypoxia-inducible factor-1α activated driver of malignancy, enhances hypoxic cancer cell proliferation, migration, and invasion in non-small cell lung cancer

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

Rajnish A. Gupta, Nilay Shah, Jeewon Kim et al. · Nature · 2010 · 5.3K citations · Full text

Life Sciences, Cancer Biology, Molecular Biology +16

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang et al. · Nature · 1999 · 5.2K citations

Medicine, Cancer Biology, Oncology +14

Cellular and developmental control of O₂ homeostasis by hypoxia-inducible factor 1α

Narayan V. Iyer, Lori E. Kotch, Faton Agani et al. · Genes & Development · 1998 · 2.5K citations · Full text

Life Sciences, Developmental Biology, Molecular Biology +16

A Long Noncoding RNA Activated by TGF-β Promotes the Invasion-Metastasis Cascade in Hepatocellular Carcinoma

Ji‐hang Yuan, Fu Yang, Fang Wang et al. · Cancer Cell · 2014 · 1.6K citations · Full text

Medicine, Cancer Biology, Molecular Biology +17

Recent cancer survival in Europe: a 2000–02 period analysis of EUROCARE-4 data

Arduino Verdecchia, Silvia Francisci, Hermann Brenner et al. · The Lancet Oncology · 2007 · 1.3K citations

Medicine, Biostatistics, Oncology +17