Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation.

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

Steffan N. Ho, Henry D. Hunt, Robert M. Horton et al. · Gene · 1989 · 7.5K citations

Life Sciences, Biotechnology, Molecular Biology +10

High-efficiency transformation of mammalian cells by plasmid DNA.

C Chen, Hiroto Okayama · Molecular and Cellular Biology · 1987 · 5.3K citations · Full text

Life Sciences, Biotechnology, Molecular Biology +13

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

Chang‐Min Kim, K. Koike, Izumu Saito et al. · Nature · 1991 · 1.2K citations

Medicine, Molecular Biology, Oncology +13

Transcriptional regulation

Nathaniel Helntz · Trends in Biochemical Sciences · 1991 · 892 citations

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

William G. Kaelin, Wilhelm Krek, William R. Sellers et al. · Cell · 1992 · 840 citations

Life Sciences, Molecular Biology, Molecular Genetics +13