Biexponential Decomposition of a Neuraminidase Inhibitor Prodrug (GS-4104) in Aqueous Solution

Influenza Neuraminidase Inhibitors Possessing a Novel Hydrophobic Interaction in the Enzyme Active Site:  Design, Synthesis, and Structural Analysis of Carbocyclic Sialic Acid Analogues with Potent Anti-Influenza Activity

Choung U. Kim, Willard Lew, Matthew A. Williams et al. · Journal of the American Chemical Society · 1997 · 1.1K citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Identification of GS 4104 as an Orally Bioavailable Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071

Weixing Li, Paul A. Escarpe, Eugene Eisenberg et al. · Antimicrobial Agents and Chemotherapy · 1998 · 224 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +14

Rearrangements Connected with the Migration of Acyl and Certain Other Groups

L. V. Pavlova, F. Yu. Rachinskii · Russian Chemical Reviews · 1968 · 40 citations

Natural Sciences, Biochemistry, Chemistry +8

Reactions of S-acylisothioureas. II. Effects of structure and stereochemistry on the rates of hydrolysis, thiol elimination, and S to N acyl migration in acylic systems

R. F. Pratt, Thomas C. Bruice · Journal of the American Chemical Society · 1972 · 31 citations

Natural Sciences, Biochemistry, Chemistry +10

Alkaline hydrolysis of 1,2,3-trisubstituted cyclic amidinium salts. Kinetic study of N → N′ acyl migration in alkaline solution in an ethylenediamine derivative

Beatriz Fernández, Isabel A. Perillo, S. LAMDAN · Journal of the Chemical Society Perkin Transactions 2 · 1978 · 20 citations

Natural Sciences, Chemistry, Organic Chemistry +8