Study the voltammetric behavior of 10-Hydroxycamptothecin and its sensitive determination at electrochemically reduced graphene oxide modified glassy carbon electrode

Abstract

The electrochemical properties of 10-Hydroxycamptothecin were investigated systematically at a reduced graphene oxide modified glassy carbon electrode. A new pair of redox peaks of 10-Hydroxycamptothecin was reported for the first time with quasi-reversible process driven by adsorption. The dynamics parameters of electrode process were calculated using various electrochemical techniques. Owing to the large surface area, good conductivity of electrochemically reduced graphene oxide, the sensor exhibited sensitive activity for 10-Hydroxycamptothecin, displaying a wide linear response from 1.5 × 10−8 mol L−1 to 5.0 × 10−7 mol L−1 and 5.0 × 10−7 mol L−1 to 3.0 × 10−6 mol L−1 (Fig. 8). A simple, sensitive and new voltammetric method for the determination of 10-Hydroxycamptothecin was proposed with a determination limit of 1.5 × 10−8 mol L−1 and recoveries were determined in the range of 94.2–104%. Keywords: 10-Hydroxycamptothecin, Electrochemically reduced graphene oxide, Determination, Electrochemical properties