Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types.

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

Zoltán N. Oltval, Curt Milliman, Stanley J. Korsmeyer · Cell · 1993 · 6K citations

Bcl-2 Heterodimerizes, Cell Regulation, Apoptosis +6

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

David M. Hockenbery, Gabriel Núñez, Curt Milliman et al. · Nature · 1990 · 3.8K citations

Mitophagy, Signal Transduction, Mitochondrial Function +8

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

David M. Hockenbery, Zoltán N. Oltvai, Xiao-Ming Yin et al. · Cell · 1993 · 3.4K citations

Medicine, Lipid Peroxidation, Apoptosis +7

Disruption of epithelial cell-matrix interactions induces apoptosis

SM Frisch, H. Francis · The Journal of Cell Biology · 1994 · 3.2K citations · Full text

Anchorage Independence, Cell Regulation, Tumor Microenvironment +15

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

Lawrence Boise, Maribel González‐García, C E Postema et al. · Cell · 1993 · 3.1K citations · Full text

Hematological Malignancy, Cell Regulation, Dominant Regulator +10