Concepedia

The NAMPT enzyme employs a switch that directly senses AMP/ATP and regulates cellular responses to energy stress

Yumeng Zu, Chou Wu, Feifei Li, Yao Hong, Ruoxi Zhang, Lulu Li, Shuangquan Chen, Qi Shi, Shuang Xi, Huanhuan Pang,

Molecular Cell · 2025 · 15 citations · 50 references

DOI

Concepts

References

50

NAD <sup>+</sup> repletion improves mitochondrial and stem cell function and enhances life span in mice

Hongbo Zhang, Dongryeol Ryu, Yibo Wu et al. · Science · 2016 · 1.2K citations · Full text

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5-Aminoimidazole-4-Carboxamide Ribonucleoside. A Specific Method for Activating AMP-Activated Protein Kinase in Intact Cells?

Julia M. Corton, John G. Gillespie, Simon A. Hawley et al. · European Journal of Biochemistry · 1995 · 1.2K citations

, , +10

(ADP-ribose)n participates in DNA excision repair

Barbara W. Durkacz, Olusesan Omidiji, Douglas A. Gray et al. · Nature · 1980 · 1.1K citations

, , +9

Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration

Toshiyuki Araki, Yo Sasaki, Jeffrey Milbrandt · Science · 2004 · 1.1K citations

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The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells

Javier R. Revollo, Andrew A. Grimm, Shin‐ichiro Imai · Journal of Biological Chemistry · 2004 · 993 citations · Full text

, , +15