Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications

Nan Xiao, Meng Nie, Huanhuan Pang, +12

Nature Communications

Targeting the Oncogene KRAS Mutant Pancreatic Cancer by Synergistic Blocking of Lysosomal Acidification and Rapid Drug Release

Chao Kong, Yang Li, Zhengsheng Liu, +10

ACS Nano

Induction of mouse totipotent stem cells by a defined chemical cocktail

Yanyan Hu, Yuanyuan Yang, Pengcheng Tan, +13

Nature

Regenerative MedicineInduced Pluripotent Stem CellDefined Chemical CocktailDevelopmental BiologyMedicine +5

Simultaneous 3-Nitrophenylhydrazine Derivatization Strategy of Carbonyl, Carboxyl and Phosphoryl Submetabolome for LC-MS/MS-Based Targeted Metabolomics with Improved Sensitivity and Coverage

Xiangjun Meng, Huanhuan Pang, Fei Sun, +6

Analytical Chemistry

Cancer-associated fibroblasts employ NUFIP1-dependent autophagy to secrete nucleosides and support pancreatic tumor growth

Meng Yuan, Bo Tu, Hengchao Li, +16

Nature Cancer

Cancer ResearchCell AutophagyPancreatic CancerNufip1-dependent AutophagyMedicine +8

Targeting acetylcholine signaling modulates persistent drug tolerance in EGFR-mutant lung cancer and impedes tumor relapse

Meng Nie, Na Chen, Huanhuan Pang, +10

Journal of Clinical Investigation

Aberrant NAD+ metabolism underlies Zika virus–induced microcephaly

Huanhuan Pang, Yisheng Jiang, Jie Li, +16

Nature Metabolism

MedicinePathogenesisViral PathogenesisVirology

Human 8-oxoguanine DNA glycosylase increases resistance to hyperoxic cytotoxicity in lung epithelial cells and involvement with altered MAPK activity

Shibichakravarthy Kannan, Huanhuan Pang, Donald C. Foster, +2

Cell Death and Differentiation

Lung Epithelial CellsBiochemistryRespiratory ToxicologyMedicineLipid Peroxidation +7

Treatment of SARS-CoV-2-induced pneumonia with NAD+ and NMN in two mouse models

Yisheng Jiang, Yong‐Qiang Deng, Huanhuan Pang, +7

Cell Discovery

Metabolic characterization of hypertrophic cardiomyopathy in human heart

Wenmin Wang, Jizheng Wang, Ke Yao, +20

Nature Cardiovascular Research

Metabolic SyndromeCardiac MuscleHeart FailureCardiomyopathyStructural Heart Disease +8