F1000Research · 2025 · 20 citations · 129 references
PharmacyEnvironmental SciencesToxicologyEnvironmental HealthEnvironmental ToxicologyHeavy Metal ToxicologyArsenic PoisoningCadmium PoisoningHeavy Metal ContaminationHeavy Metal Reproductive ToxicityLead PoisoningMetal ToxicityEnvironmental Metal ContaminationHeavy Metal Contamination In Agricultural SoilsHeavy Metal ExposureHuman Health EffectsMercury Reproductive ToxicityMetal Toxicity In SoilMining-related Heavy Metal Pollution
<ns3:p>Heavy metal contamination has gradually become a highly significant global issue due to its continual existence in the environment and bioaccumulation in the ecosystems, posing deleterious risks to human health. This review aims to investigate the sources, pathways, and toxicological impacts of heavy metals such as cadmium, lead, mercury, and arsenic, elucidating their health consequences and plausible mitigation strategies. Furthermore, the review explores the dual origins of heavy metal contamination; natural geological processes and anthropogenic activities such as industrial emissions, mining, and agricultural practices. These heavy metals seep into soil, water, and food chains, leading to bioaccumulation, bio-magnification and causing significant health risks, including cardiovascular diseases, neurological disorders, and reproductive toxicity. Additionally, the addition of indigenous case studies from Nigeria, such as lead poisoning in Zamfara State and contamination in the Great Kwa River of Cross Rivers State underscores the disproportionate impact of heavy metal pollution in developing nations. These case studies reveal the socio-economic and environmental dimensions of the issue, providing a contextual understanding of region-specific vulnerabilities and health outcomes. To address these problems, the review evaluates already existing mitigation strategies, including chelation therapy and phytoremediation, while proposing sustainable, cost-effective solutions for reducing exposure and mitigating impacts. It emphasizes the importance of integrative approaches involving policy, community engagement, and technological innovations to fight heavy metal contamination effectively. In conclusion, this seminar contributes to the understanding of heavy metal toxicity, giving and showcasing very much important insights into the sources and health implications of contamination. By integrating theoretical perspectives with practical solutions, this review provides a robust framework for informing policy makers and advancing sustainable environmental management practices.</ns3:p>
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Free Radical Properties, Source and Targets, Antioxidant Consumption and Health
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