Concepedia

Mechanical stress overload promotes NF-κB/NLRP3-mediated osteoarthritis synovitis and fibrosis through Piezo1

Likai Yu, Tian Di, Zishan Su, Zhang Li, Lishi Jie, Shaobo Guo, Wenhui Zhu, Peimin Wang

Cellular Signalling · 2025 · 21 citations · 39 references

DOI

Concepts

References

39

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

Bertrand Coste, Jayanti Mathur, Manuela Schmidt et al. · Science · 2010 · 3.2K citations · Full text

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NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

Auvro R. Mridha, Alexander Wree, Avril A. B. Robertson et al. · Journal of Hepatology · 2017 · 1.1K citations · Full text

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Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation

Julián Albarrán-Juárez, András Iring, Shengpeng Wang et al. · The Journal of Experimental Medicine · 2018 · 326 citations · Full text

, , +17

Structure deformation and curvature sensing of PIEZO1 in lipid membranes

Xuzhong Yang, Chao Lin, Xudong Chen et al. · Nature · 2022 · 290 citations

, , +16

Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis

Yusuke Hirata, Ruiqi Cai, Allen Volchuk et al. · Current Biology · 2023 · 246 citations · Full text

, , +17