Enzymatically responsive nanocarriers targeting PD-1 and TGF-β pathways reverse immunotherapeutic resistance and elicit robust therapeutic efficacy

Integrating single-cell transcriptomic data across different conditions, technologies, and species

Andrew Butler, Paul Hoffman, Peter Smibert et al. · Nature Biotechnology · 2018 · 14.1K citations · Full text

Engineering, Genetics, Multiomics +17

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Sanjeev Mariathasan, Shannon J. Turley, Dorothee Nickles et al. · Nature · 2018 · 5.2K citations · Full text

Tumor Biology, Cancer Immunosurveillance, Tumour Response +12

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

Sydney Gordon, Roy L. Maute, Ben W. Dulken et al. · Nature · 2017 · 2.2K citations · Full text

Inflammation, Cancer Immunosurveillance, Pd-1 Expression +9

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

Daniele V. F. Tauriello, Sergio Palomo‐Ponce, Diana Stork et al. · Nature · 2018 · 1.7K citations

Immune Evasion, Cancer Immunosurveillance, Immunology +5

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

Alfiya Akhmetshina, Katrin Palumbo, Clara Dees et al. · Nature Communications · 2012 · 818 citations · Full text