Concepedia

Exploration of anti-inflammatory activity of pyrazolo[3,4-d]pyrimidine/1,2,4-oxadiazole hybrids as COX-2, 5-LOX and NO release inhibitors: Design, synthesis, in silico and in vivo studies

M. Abdel Aziz, Ibrahim M. Salem, Mohammed A. AlAwadh, Abdulrahman S. Alharbi, Deiaa E Elsayed Abouzed, Rasha M. Allam, Osama A. A. Ahmed, Tarek S. Ibrahim, Gamal El‐Din A. Abuo‐Rahma, Mamdouh F. A. Mohamed

Bioorganic Chemistry · 2025 · 17 citations · 43 references

DOI

Concepts

References

43

Development and Testing of the OPLS All-Atom Force Field on Conformational Energetics and Properties of Organic Liquids

William L. Jorgensen, David S. Maxwell, Julian Tirado‐Rives · Journal of the American Chemical Society · 1996 · 15.3K citations

, , +17

Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs

C. A. Winter, Edwin A. Risley, George W. Nuss · Experimental Biology and Medicine · 1962 · 5.7K citations

, , +7

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

Daniel Picot, Patrick J. Loll, R. Michael Garavito · Nature · 1994 · 1.3K citations

, , +11

The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life

Jane L. Wang, David C. Limburg, Matthew J. Graneto et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 335 citations · Full text

, , +15

Crystal Structure of Inhibitor-Bound Human 5-Lipoxygenase-Activating Protein

Andrew D. Ferguson, Brian M. McKeever, Shihua Xu et al. · Science · 2007 · 225 citations

, , +15