Effects of Regulators of G Protein-Signaling Proteins on the Functional Response of the μ-Opioid Receptor in a Melanophore-Based Assay

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

Hans W. D. Matthes, Rafaël Maldonado, Frédéric Simonin et al. · Nature · 1996 · 1.7K citations

Medicine, Neuroscience, Pharmacology +17

Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors

Ja‐Hyun Baik, Roberto Picetti, Adolfo Saiardi et al. · Nature · 1995 · 648 citations

Life Sciences, Neurobiology, Neuroscience +14

Role for G protein-coupled receptor kinase in agonist-specific regulation of μ-opioid receptor responsiveness

Jie Zhang, Stephen S. G. Ferguson, Larry S. Barak et al. · Proceedings of the National Academy of Sciences · 1998 · 511 citations

Medicine, Molecular Biology, Pharmacology +17

Regulators of G-Protein Signaling (RGS) Proteins: Region-Specific Expression of Nine Subtypes in Rat Brain

Stephen J. Gold, Ni Yan, Henrik Dohlman et al. · Journal of Neuroscience · 1997 · 434 citations · Full text

Life Sciences, Neurobiology, Neuroscience +9

RGS proteins reconstitute the rapid gating kinetics of Gβγ-activated inwardly rectifying K ⁺  channels

Craig A. Doupnik, Norman Davidson, Henry A. Lester et al. · Proceedings of the National Academy of Sciences · 1997 · 340 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17